So how do cannabinoids, such as those found in CBD oil, actually work with our internal endocannabinoid system? Simply put, cannabinoids act by binding or triggering our internal receptors. Overall, cannabinoids are known to offer “negative feedback” to our neurons. For example, when somebody is suffering from pathological conditions, such as strokes or epilepsy, it is because the neurons are overexcited. By inhibiting such neurons, cannabinoids help decrease the activity of the target cells and helps protect it from over-excitement of the neurons.

Thus, cannabinoids along with the endocannabinoid system work as part of the body’s “general protective network, working in conjunction with the immune system and various other physiological systems,” according to Dr. Mechoulam

Why Take CBD Oil When Our Body Generates Endocannabinoids?
So if our body naturally creates cannabinoids, why do we need to intake more through phytocannabinoids, such as CBD? Researchers have come up with several different reasons why humans could be deficient of endogenous cannabinoids. This could be the result of poor diet, lack of exercise, drug abuse, environmental toxins, chronic stress, or even genetic factors. Thus, cannabinoids derived from cannabis can be tremendously helpful to boost our internal cannabinoid levels.


As a society, we have been cannabinoid deficient for many decades, considering hemp and cannabis have been prohibited for most of the 20th century. Now that science has come to validate historical anecdotal evidence that cannabis offers numerous health benefits, we can only hope for continued deregulation of hemp. So maybe one day, we can freely take cannabis extracts as a daily supplement.

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